Erectile dysfunction (ED) is a serious, life-altering problem for millions of men. A man’s inability to achieve or maintain an erection is inevitably linked to complex feelings of inadequacy, frustration, and shaken confidence, which may spill over into other areas of his life.
Since the introduction of Viagra (sildenafil citrate) in 1998, several other drugs for the treatment of ED have been introduced; it has become clear that ED is far more prevalent than may have been suspected previously.
It is important for men to test their blood levels of free testosterone and estradiol (an estrogen). As men age, they often suffer from a deficiency of free testosterone while producing too much estrogen. Sexual desire and performance are strongly affected by these hormones. The good news is that there are safe ways of increasing free testosterone and reducing excess estrogen, which can lead to a significant improvement in a man’s sexual satisfaction.
Anatomy of an Erection
The male sex organ is largely under the control of the central nervous system. The features that allow erection to occur consist of spongy columns of tissue known as the corpus cavernosum and corpus spongiosum. When these specialized tissues engorge with blood, erection is achieved. This process, however, is quite complicated, involving complex interactions among psychological and physical stimuli and chemical signals, as well as a shifting balance between inhibitory and excitatory forces.
During sexual stimulation, the brain sends signals that result in the release of nitric oxide by parasympathetic neurons in the penis. Penile endothelial cells are also stimulated to release nitric oxide. As nitric oxide diffuses into the smooth-muscle cells lining the arteries of the corpus cavernosum and corpus spongiosum, it stimulates the activation of an enzyme called guanylate cyclase. This enzyme produces cyclic guanosine monophosphate (cGMP), which prompts the smooth muscles of penile arteries to relax, allowing more blood to flow into the spongy tissues of the penis. Simultaneously, blood return via penile veins is restricted, trapping blood in the organ, resulting in engorgement and erection.
Eventually, cGMP is broken down by phosphodiesterase type 5 enzymes (PDE5). When this occurs, the erection subsides; blood flow returns to normal, and the penis resumes its normal flaccid state.
Viagra, for instance, are selective inhibitors of PDE5. By inhibiting the degradation of cGMP, which is the direct intracellular mediator of the nitric oxide pathway, these drugs promote better erections
Role of Nitric Oxide
Nitric oxide allows more blood to flow into the spongy tissues of the penis. Simultaneously, blood return via penile veins is restricted, trapping blood in the organ, resulting in engorgement and erection. Noni increases the production of nitric oxide in your body in a natural way. Thus the person suffering from ED can get a satisfactory positive result of using Noni.
Noni has been shown to improve ED and other nitric oxide–dependent conditions, including atherosclerosis. Glycosides present in Noni increase the release of nitric oxide in the body.
Risk factors for ED include conditions such as high blood pressure, abnormally high blood lipids (i.e., elevated low-density lipoprotein cholesterol and triglycerides), obesity, diabetes, and smoking. Noni helps also in reducing blood pressure as many ingredients in Noni acts like vasodilator. Noni also stimulate to produce more nitric oxide in our body that helps in reducing the blood pressure. The phytosterols present in Noni prevents the absorption cholesterol from intestine and thus reduces the level of cholesterol in your blood. Noni also helps in diabetes. Thus the risk factors for ED can be minimize if used Noni for a longer period.
Oxidative stress plays a role in ED among diabetics. Noni is effective antioxidants as it contains all the antioxidant vitamins; all trace minerals, and lots of phytochemicals. Noni also enhances the synthesis of endogenous antioxidants in our body. The 3 antioxidant enzyme glutathione peroxidase, superoxide dismutase, catalase are synthesized more by the stimulatory effect of Noni. Hence Noni can relieve the oxidative stress related ED by its strong antioxidant property.
ED has been associated with declining levels of dehydroepiandrosterone (DHEA), an important hormone that tends to be depleted steadily with age. Noni contain all the phytosterols. Phytosterols are plant based sterols that act as precursors to human sterols. The most important human sterol is Dehydroepiandrosterone (DHEA). Hence Noni may enhances the DHEA level.